zaterdag 3 mei 2008

Addition to previous post

In addition to the previous posting about the protein assemblage, it is stated in the text books that the mRNA template (molecule) specifies precisely in which order aminoacids must be added to the peptidechain. It is a rather linear process, which in Young's model is associated with substage 5 operations.

Furthermore, the correct aminoacids are delivered by transfer RNA. These acids
are attached to tRNA by specific enzymes. Many factors are involved in this process, not dealt with here: initiation, charging, decoding, formation of peptide bonds and subsequent splitting of  the aminoacid from the transfer RNA, multiple proteins being synthesized at the same time, the formation of vesicles, etc.

The question remains how the cell knows which aminoacids to deliver at that junction of time and place and when and where and how the decision to do so takes place. There are still many unknown features as to recognition/
decision capabilities of the cell.

Can one say that the decoding of the template (mRNA) is analogous to processing data? And that substage 5 involves instructions that are executed? It certainly entails a complex organization in order to be able to synthesize proteins. Is the product, a protein, or rather, proteins, to be considered a substage 4 result which is subsequently packaged in a vesicle? We will have to investigate these matters more thoroughly, guided by  Young's model and my own model as well. Analogy in process will be another guideline.