Addition to previous post

In addition to the previous posting about the protein assemblage, it is stated in the text books that the mRNA template (molecule) specifies precisely in which order aminoacids must be added to the peptidechain. It is a rather linear process, which in Young's model is associated with substage 5 operations.

Furthermore, the correct aminoacids are delivered by transfer RNA. These acids
are attached to tRNA by specific enzymes. Many factors are involved in this process, not dealt with here: initiation, charging, decoding, formation of peptide bonds and subsequent splitting of  the aminoacid from the transfer RNA, multiple proteins being synthesized at the same time, the formation of vesicles, etc.

The question remains how the cell knows which aminoacids to deliver at that junction of time and place and when and where and how the decision to do so takes place. There are still many unknown features as to recognition/
decision capabilities of the cell.

Can one say that the decoding of the template (mRNA) is analogous to processing data? And that substage 5 involves instructions that are executed? It certainly entails a complex organization in order to be able to synthesize proteins. Is the product, a protein, or rather, proteins, to be considered a substage 4 result which is subsequently packaged in a vesicle? We will have to investigate these matters more thoroughly, guided by  Young's model and my own model as well. Analogy in process will be another guideline.

Creation and selection: level 2; production : level 3,4

In my preliminary seven stage, four level model of earth development I follow the general ideas of Kabbalah and theosophy. I also use elements of John Bennett's systematics and Arthur Young's theory of process and some of Jim Miller's Living Systems Theory (and some other stuff).
I prefer to work somewhat with Miller's subsystems (Link to cell subsystems and link to organism subsystems) rather than separate structures/components, simply because it provides a cleaner overview of process. Miller discusses the fact that components of cells can be involved in several subsystems (such is the case with the plasmamembrane) and a subsystem can comprise several components. There is not a 1-1 relation between subsystems and components of a cell. It is a n:m relation. Keep this in mind.
So, we must be careful in putting a component on a certain level or sublevel of Young's model. Rather, I prefer to use my own model (which is in its beginning phase of development) to describe functions and relations to structures/components.

It occurred to me recently that I can fit in some basic aspects of cell function into my model. For example, stage 5 in my model shows development of the cell. As I have stated before, I see substage 1 as an archetype for subsequent stages. It contains the substantial pattern or template that has to be used for manifestation, so to speak. It is a clear matter in the case of cells: DNA contains the information pattern necessary to synthezise proteins. On level 2 there is an interaction of proteins, notably enzymes, with the DNA in the nucleus. In the transciption phase of protein synthesis, a small part of the long DNA strand is transcribed (copied) into a pre-RNA molecule (in case of the eucaryotic cell) which is subsequently processed into a regular mRNA molecule. This is clearly a selection out of many possible patterns that make up the DNA. In this process, information is coupled to substance (the elements that make up the mRNA and pre mRNA, also the energy needed to do the work involved). Note that creation entails limitation. It cannot be otherwise. How could it?

The mRNA molecule is then transported out of the nucleus to the endoplasmatic reticulum where it is processed (its code is translated into aminoacids, constituting the protein, it is coding for). This concerns an assemblyline like processing ("substage 5" like, level 3 which works with a "stage 3" substantial template - mRNA which is transported through a ribosome) which involves decoding (translating) the informationmarkers of the mRNA into the instructions for making the right aminoacids and assembling these into proteins, all done by ribosomes and transfer RNA (these form the producer). Formation of peptide bonds takes place here.

Stage 3, 4 ,5 of my model (and possibly Young's model) can be very loosely mapped onto the subsystems of Miller, as follows: Decoder, Converter, Producer. I said loosely, because a closer study of matter-energy subsystems working in association with information processing subsystems is necessary, and a further development of my model is also necessary. Stage 4 might be the production of the aminoacids which are then assembled into proteins. 3-4-5 works as a whole, together.

Note the different domains where transcription and translation take place: the nucleus versus the cytosol. We may be able to establish an analogy with other processes, like the human act of will or the physiological organism, to name a few, later on.

Adaptive matters...

When the protein has been synthesized it buds off the ER in the form of a vesicle and is transported or moves from the ER to the Golgi-complex (research is still going on in that respect).

The Golgi apparatus is very interesting. It has many functions: from sorting and packaging proteins, to modifying proteins, synthesizing molecules, and a role in apoptosis (decision/choice to die as a cell or not to die is involved), to name some.
This requires discrimination (typically a sixth "stage" function) as will become clear when you reflect on these functions. Remember my previous blogposting where I briefly discussed the Mars and Scorpio functions? If not, have a look again, it contains some very interesting points (likely applicable beyond the cell, to organisms and the human being in its psychological aspects).
Also, after production (synthesis) of a protein, a fifth stage function, ending with bubble like vesicles, one would expect a sixth stage to occur, and this may well be the activity of the Golgi complex. The seventh stage would be activity at the plasmamembrane, something to consider at a later point.


My point in this brief note is to put emphasis on the selection part of level two and the collaboration of left and right parts of the arc of my model. Principles working or being expressed through the elements. Subsystems at work.
On the human level, concerning mind, one can draw a strong analogy with the process of decision making (the act of will, the complete process). First there is a "seed-idea" - level 1, substage 1 - that enters the mind, that may be very general (a purposive thing). It comprises many possible courses of action, subgoals, etc. Before one decides about anything, there is usually a phase of deliberation - level 2, a weighing of alternative ideas, strategies, connected to the main idea or purpose.
Then a decision ("stage 6" function) is made concerning which goal to pursue and how to do it, which strategy/tactics to implement.
This bears on methods, means, etc., so it couples idea to substantial means. It usually involves money too (a kind of bearer of value!) and in general is based on a belief-system, moral values, etc. The decision also involves motivation (energetic aspect). If one has enough motivation or a high sense of duty one will decide positively for a lofty purpose.
Later an action plan is developed ("stage" 5 function: planning function of the mind involves the process of sequencing of steps (ordering). It yields a plan of action, ("stage 3" blueprint). See how the left and right parts of the arc relate to each other here? Finally the actionplan is executed (bound to a particular time and place)("stage 4"), which involves control (feedforward commands, possibly a "stage 6" function but often downwardly dispersed as far as possible in hierarchical systems), and feedback to adjust the execution and plan to circumstances. See also my post on Assagioli - the stages of the act of will.

More study is needed to develop the model. Some insights have been gained as to selection/copy processes on level 2 of the model. Level 3 and 4 are seen to entail decoding/conversion/production, something to consider in more detail.
Analogies can be further developed since they are like the salt in the dinner.
It's all time consuming, a lot of comparitive study necessary, but the rewards of developing insight into the intricate workings of nature on many levels of being is great, I believe.

substage 5

Substage 5 is about control of form. In humans (level 1, stage 7 Young), creativity shows itself at work (substage 5). Young puts creative genius in this substage. This genius certainly has an ego (quite an ego, at times). The big transformation of the ego/self is something that occurs in substage 6.

In plants (typifying stage 5), there is, in substage 1 of stage 5 of the Young model, the appearance of the cell. First there is the proto-cell, the prokaryote, sometimes called microbe. Later we get the eukaryote. These microbes of substage 1 seem to play a role in the evolution of the cell, as in endosymbiosis - for example, the mitochondrion in the cell.  One of the striking features of stage 5 is the presence and activity of membrane organizers. Negentropy or syntropy is only possible if there is some kind of boundary imposed between a center and its environment. Vesicles play an important role in the cell, something to be studied in more detail.

The phospholipid bilayer forms the plasmamembrane, together with certain classes of proteins.These phospholipids can form rings or other closed structures - very interesting indeed. The double feature of hydrophobic tails and hydrophilic heads is something we must keep in mind. Is this bipolarity reproduced in nature on other levels and scales?

On a more esoteric note, the mind has its own enclosure. "Closedmindedness"  is not just a linguistic phrase. The human aura is composed of many layers ("membranes") with pores in it, according to the eminent esoterist De Purucker. I suppose that many people would be very surprised if they would get to know more about the functions of  the human aura/consciousness. The projections of the mind are many and varied - a subject shrouded in mystery.

More on level two and three

To continue where I left off in my previous posting: level two seems to entail the source of cycles. Very mystically, the Aeons represent time-periods in which particular facets of consciousness/energy are being developed. We can also expect something like "timers", "pacers", etc., to have their origin here. The notion of recurrence has already been mentioned in respect to hyparxis and autopoiesis. Organisms have to maintain themselves, homeostasis, etc. and they need food/energy from outside sources to do that. Exchange of substances, circulation in a sense is expected to accomplish that feature.

Level three shows the building of form, the organization of form and function, in the Young model there is stage 3, the taking on of a center. In esoteric teaching there is the idea of elementals (micro-elements, life-atoms, whatever you want to call these building blocks of life) taking a form that is organized by some (semi)conscious factor - be it plants, animals or humans. We can take stage 5 and stage 6 as the ensemble of psychophysiological forces, in stage 5 less developed qualities and in stage 6 more or higher developed qualities - something to research a little deeper. Keep in mind that plants are not the stupid creatures one might be inclined to think. No, there is now proof that some plants recognize certain predators and produce chemicals to attract the enemies of such predators. A guy at Wageningen University  has researched that stuff, I believe for his PhD. Fascinating.

Stage 4 can be taken as a combination of combinations between "stages" (be it substances, elements, functions). In a simple way one can look at this stage as the infrastructure ("body") of an organism, and look at the psychological/cognitive functions as higher "stages" (or possibilities, spheres, influences, functions, energies) expressing themselves through the body. It all boils down to a very intricate meshwork of hierarchical-heterarchical components forming an ensemble, sometimes designated as holarchy. I suppose that biologists know quite some things about  the cell at this point in time (certainly more than about embryology), so this might provide a good starting point for a study of biological process.

Comparing Bennett's ideas to Young's work

Comparing the ideas of Arthur Young with John Bennett can be fruitful. It made me realize that Bennett's hyparxis, a time-like power, actually has a lot to do with level two in the Young model. In modern parlance one could say that agency has to do with level two (and with level one). Will, related to the concept of hyparxis,  is active on level two. On a similar note, we can say that the Ancients related Kundalini, the Life-force or shakti, to adaptation of and to the environment. As I have written in an evaluative article about Young (see my ebook),  level two has to do with interaction with the environment taken in the widest sense.

The 'axis'  Level two-Level one seems to me correlated to the inner flow of consciousness. Also, decision making seems to involve level two (emotions, a.o. in the Young model, stage 6) and level one. Lots to research!

On a sidenote: Bennett associates the property of 'spin' with hyparxis (for photons/elementary particles). Something to keep in mind. Light is the connecting factor between the Macro, level 1, and level two ('soul' level in Young's model). Stage six is important in my own fourfold model as it is the intermediate regulating factor between level 1 and the lower levels.

Interaction and events seem primary to time to me. Time looks like an abstraction. Thinking about this, I realized that a proper designation for level two might be something like 'Duration', rather than time. It also is the level where all kinds of elements are unfolded from the bosom of level one. Stage two in Young's model could be correlated  with the Serpent force (Kundalini) about which Subba Rao had some interesting things to say. More about him in another posting.

One more thing: stage six is on the right side of the sevenfold arc as per Young. It seems to have to do with regulation (astrological symbol: planet Mars). Sometimes the ancient symbol of Scorpio (generation) is associated with stage 6 (which can also be taken as transformation in a spiritual sense - when appropriate. There is so much symbology applicable here. Think of the Eagle with the serpent in its claws - the symbol of regulated life-force, ideally spiritual Regeneration.). Stage two has also designated a symbol: Jupiter-Zeus-Chronos (Chronos as Duration rather than time!). How Sagittarius fits in is not entirely clear to me, but it seems to be correlated with the many classes of micro-elements that are generated at this level. In esoterism, the nine prajapatis (with Jupiter making the tenth) seem to be mightily involved with this - the Gnostics have their system of Aeons (Time-Duration again!) which has a whole lot of meanings attached (see Simon Magus in his Gnostic system).

What I am looking for in all this is formost generative force, regulation, interaction, adaptation, selection out of available options, choice, to name a few correlatives to this level. One can expect that biological systems will display some or all of these features. Recurrent life (force) is something that can be correlated with hyparxis too, and it makes sense when we think about autopoietic systems that rebuild themselves constantly.

It pays off to do some study of ancient symbols when researching the fundaments of a true holistic science!

Comparing Bennett to Young

Comparing the ideas of Arthur Young with John Bennett's can be fruitful. It made me realize that Bennett's hyparxis, a time-like power, actually has a lot to do with level two in the Young model. In modern parlance one could say that agency has to do with level two (and with level one). Will, related to the concept of hyparxis,  is active on level two. On a similar note, we can say that the Ancients related Kundalini, the Life-force or shakti, to adaptation of and to the environment. As I have written in an evaluative article about Young (see my ebook),  level two has to do with interaction with the environment. Level two-level one seems to me correlated to the inner flow of consciousness. Also, decision making seems to involve level two (emotions, a.o.) and level one. Lots to research!

On a sidenote: Bennett associates the property of 'spin' with hyparxis (for photons/elementary particles). Something to keep in mind. Light is the connecting factor between the Macro, level 1, and level two ('soul' level in Young's model). Stage six is important in my own fourfold model as it is the intermediate regulating factor between level 1 and the lower levels.

Interaction and events seem primary to time to me. Time looks like an abstraction. Thinking about this, I realized that a proper designation for level two might be something like 'Duration', rather than time. It also is the level where all kinds of elements are unfolded from the bosom of level one. Stage two in Young's model could be correlated  with the Serpent force (Kundalini) about which Subba Rao had some interesting things to say. More about him in another posting.

One more thing: stage six is on the right side of the sevenfold arc as per Young. It seems to have to do with regulation (astrological symbol: planet Mars). Sometimes the ancient symbol of Scorpio (generation) is associated with stage 6 (which can also be taken as transformation in a spiritual sense - when appropriate. There is so much symbology applicable here. Think of the Eagle with the serpent in its claws - the symbol of regulated life-force, ideally spiritual Regeneration.). Stage two has also designated a symbol: Jupiter-Zeus-Chronos (Chronos as Duration rather than time!). How Sagittarius fits in is not entirely clear to me, but it seems to be correlated with the many classes of micro-elements that are generated at this level. In esoterism, the nine prajapatis (with Jupiter making the tenth) seem to be mightily involved with this - the Gnostics have their system of Aeons (Time-Duration again!) which has a whole lot of meanings attached (see Simon Magus in his Gnostic system).

What I am looking for in all this is for most generative force, regulation, interaction, adaptation, selection out of available options, choice, to name a few correlatives to this level. One can expect that biological systems will display some or all of these features. Recurrent life (force) is something that can be correlated with hyparxis too, and it makes sense when we think about autopoietic systems that rebuild themselves constantly.

substance philosophy

To get a feel for the importance of substance in the continuity of life and many other issues, you could study books like: "The Possibility of Metaphysics: Substance, Identity, and Time"  by E. J. Lowe; Clarendon Press, 1998.

For now, I direct my attention to the process of creation as a whole, but I'll come back to considerations of substance when necessary to my investigations. Keep in mind that I use the old Eastern method of study: first get a global picture, then descend into more detailed descriptions. Ponder about these things and your intuition will develop alongside with your experience in life.